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KMID : 0374920110320010065
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Inje Medical Journal
2011 Volume.32 No. 1 p.65 ~ p.71
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A Case of Agranulocytosis due to Re-exposure to Antithyroid Agent in a Patient with Relapsed Graves' Disease
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Kim Seung-Man
Kim Tae-Young
Park Su-Young
Bae Young-Hwan
Seo Young-Kyeong
Jung Eun-Joo
Kim Tae-Kyoon
Kwon Min-Jeong
Park Jeong-Hyun
Lee Soon-Hee
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Abstract
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Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.
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KEYWORD
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Agranulocytosis, Antithyroid agents
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